http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2021506814-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-545 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-64 |
| filingDate | 2018-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2021506814-A |
| titleOfInvention | Degradation of target proteins mediated by stabilizing peptides |
| abstract | The present application combines a staple peptide that binds to a disease-related protein with a small molecule degron, eg, celebrone or VHL binding small molecule as degron, or a polypeptide sequence degron, eg, a Cop1-binding trib peptide as degron; or staple peptide de. Described is a staple peptide degron chimera that acts as a proteolytic moiety by combining gron with a peptide such as a staple peptide or a small molecule that binds to a disease-related protein. The application is also a method of targeted degradation of endogenous proteins by using the staple peptide degron chimera, which can be used in the treatment of proliferative disorders or other conditions to cause disease or disease-related proteins. Disappears and may have therapeutic benefits. The application also provides methods for making the compounds of the application and their intermediates. |
| priorityDate | 2017-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 20.