| abstract |
The present invention relates to a recombinant adenovirus having excellent ability to be introduced into stem cells and which can be well introduced into stem cells even at a low concentration, stem cells containing the same, a composition for gene transfer, and a pharmaceutical composition. Stem cells into which adenovirus has been introduced have excellent residual capacity in the body and therapeutic effect on tumor cells, do not induce problems such as residual stem cells in the body or hepatotoxicity when used as an anticancer agent, and are particularly useful for systemic administration. It has an excellent anticancer effect even at a low dose, and is widely used as an anticancer agent using adenovirus. |