http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2021505544-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-141 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0048 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-713 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-713 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| filingDate | 2018-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2021505544-A |
| titleOfInvention | MiR29 mimic for the treatment of ocular fibrosis |
| abstract | Provided herein are miR-29 double-stranded chemically modified oligonucleotide mimetics for use in the treatment of eye diseases or disorders associated with ocular fibrosis and fibrosis of the eye. In one aspect, a method of treating ocular fibrosis in a subject is provided, the method comprising administering to the subject a therapeutically effective amount of a miR-29 mimic compound, wherein the miR-29 mimic compound ( a) First strand of 23-26 ribonucleotides comprising a mature miR-29a sequence, a mature miR-29b sequence or a mature miR-29c sequence; and (b) a sequence substantially complementary to the first strand. The eye comprises a second strand of 22-23 ribonucleotides comprising and having at least one modified nucleotide, said first strand having a 3'nucleotide overhang with respect to said second strand. Fibrosis includes retinal fibrosis, corneal fibrosis, conjunctivitis or trabecular meshwork fibrosis. |
| priorityDate | 2017-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 186.