| abstract |
The present invention comprises an as-membered nitrogen-containing heteroaryl ring attached to a sulfonyl group, the heteroaryl ring being substituted with at least one group containing an oxygen atom, wherein the oxygen atom is With respect to sulfonylureas and sulfonylthioureas attached to the heteroaryl ring via at least two other atoms. The invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions containing such compounds, and most specifically to the treatment and prevention of medical disorders and diseases by inhibition of NLRP3. With respect to the use of such compounds in. [Selection diagram] None |