| abstract |
PROBLEM TO BE SOLVED: To provide an aryl receptor modulator and a method for producing and using the same. The present invention generally relates to compounds capable of binding and modulating the activity of aryl hydrocarbon receptors, methods of treating inflammatory conditions such as Crohn's disease using such compounds, and the like. The target is a pharmaceutical composition containing such a compound. Also provided are methods of increasing IL-22 levels of a subject and / or reducing IFN-γ levels of a subject. The inflammatory diseases or conditions treated by the compounds of the present invention include inflammatory bowel disease, cartilage inflammation, osteolysis, ulcerative colitis, psoriasis, arthritis, psoriasis arthritis, rheumatoid arthritis, juvenile arthritis, juvenile joints. A group consisting of rheumatism, autoimmune hepatitis, Crohn's disease, lupus erythematosus, multiple sclerosis, Alzheimer's disease, dermatitis, atopic dermatitis, psoriasis, type I diabetes, Reynaud's phenomenon, Graves' disease, and Azison's disease. Will be selected. [Selection diagram] None |