| abstract |
PROBLEM TO BE SOLVED: To provide a composition and a method for treating a neurodegenerative disease such as amyotrophic lateral sclerosis and frontotemporal dementia. SOLUTION: A modified oligonucleotide consisting of 12 to 30 linked nucleosides is contained, and at least 8, at least 9, at least 10, at least 11, at least 12, at least 13, at least 14 of any of a specific nucleic acid base sequence group. , A compound having a nucleobase sequence containing at least 15, at least 16, at least 17, or at least 18 consecutive nucleobases, a composition comprising the nucleobase. [Selection diagram] None |