| abstract |
PROBLEM TO BE SOLVED: To inhibit activated plasma kallikrein (PK) capable of acting toward fibrinolysis of an occlusive thrombus, promoting reperfusion, weakening a hypercoagulable state, and preventing thrombus remodeling and vascular reocclusion. I will provide a. SOLUTION: The compounds and pharmaceutical compositions of Formula I, as well as methods of using the compounds and compositions for the treatment and prevention of diseases and conditions characterized by unwanted PK, are provided. [Selection diagram] None |