| abstract |
PROBLEM TO BE SOLVED: To provide a safe and well-tolerated norepinephrine transporter inhibitor having predictable pharmacokinetic properties for use in the treatment of noh. The present invention is the pharmaceutically of 4- [2- (2,4,6-trifluorophenoxymethyl) -phenyl] piperidine for the treatment of neurogenic orthostatic hypotension and its symptoms. Regarding the use of acceptable salt. In one aspect, the invention is a compound of formula I or a pharmaceutically acceptable salt thereof for use in the treatment of neurogenic orthostatic hypotension and its symptoms in human patients, at about 1 mg / day. Administered to a patient in an amount ranging from ~ about 20 mg / day and used, (a) increased sitting systolic blood pressure in the patient; (b) increased standing time in the patient; or (c) dizziness or dizziness experienced by the patient. With respect to compounds, characterized by diminished consciousness. [Selection diagram] None |