| abstract |
PROBLEM TO BE SOLVED: To provide a compound having cytotoxicity and / or antimitotic activity. Methods related to the preparation and use of such compounds, as well as pharmaceutical compositions containing such compounds are also disclosed. Structure: It has (T)-(L)-(D), (T) is the target moiety, (L) is the optional linker, and (D) is cytotoxic and / or anti-mitotic. Compositions that are compounds with mitotic activity are also disclosed. [Selection diagram] Fig. 1 |