| abstract |
PROBLEM TO BE SOLVED: To provide an antibody capable of blocking a PD-1 / PD-Ls signal transduction pathway for antitumor. Based on a parental human PD-1 mouse monoclonal antibody that specifically binds to a protein of human PD-1, the sequence of its CDR region was confirmed and constructed by cloning, identification, and analysis of gene structure. Chimeric antibodies and humanized antibodies. Antibodies include a light chain CDR consisting of CDR-L1, CDR-L2, CDR-L3 having a specific sequence, and a heavy chain CDR consisting of CDR-H1, CDR-H2, CDR-H3 having a specific sequence. [Selection diagram] Fig. 4 |