| abstract |
PROBLEM TO BE SOLVED: To provide a novel inhibitor for a bromodomain of a BET protein, which is effective for various diseases including various cancers. SOLUTION: The quinazoline, quinoline or isoquinoline derivative represented by the following formula I is used. (X and Z are CH or N independently, Y is H, Cl, C 1 to 6 alkyl, etc .; L 1 is-(CR 9 R 10 ) n- , -C (O)-or-S (O) 2- ; R 9 and R 10 are independently H or substitutable C 1 to 6 alkyl; n is 0, 1, 2 or 3; R 1 is substitutable C 6 to 10 aryl or 1 or more N, O or 5 to 10-membered substitutable heteroaryl containing the S atom as a heteroatom; R 2 is H, C 1 to 6 alkyl, etc .; R 3 and R 4 are independently H, C 1 to 6 alkyl, etc.) [Selection diagram] None |