http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2021108572-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24aca9ded2638ea793d05360dde7a4a0 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F265-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 |
| filingDate | 2020-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7d1848283fb2fe175a9bdeac936b9085 |
| publicationDate | 2021-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2021108572-A |
| titleOfInvention | Substrate for solid-phase nucleic acid synthesis and its manufacturing method |
| abstract | PROBLEM TO BE SOLVED: To provide a base material for solid phase nucleic acid synthesis capable of supporting a nucleoside linker or a universal linker with a high loading amount, a method for producing the same, and the like. A method for producing a base material for solid phase nucleic acid synthesis, which comprises the following steps. (1) A step of reacting an inorganic particle having a hydroxyl group on the surface with a silane coupling agent having a terminal double bond to covalently bond the silane coupling agent to the surface of the inorganic particle; (2) Step (1) ) Has a group (x) selected from the group X (amino group, hydroxyl group, amino group protected by a protective group, and hydroxyl group protected by a protective group) and a terminal double bond. A silane coupling agent that covalently bonds to the surface of the inorganic particles while dispersing the inorganic particles obtained in the steps (3) and (2) in a non-polar solvent. And the compound (A) are radically copolymerized to prepare inorganic particles in which the polymer having the group (x) is covalently bonded to the surface. [Selection diagram] None |
| priorityDate | 2020-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 442.