| abstract |
PROBLEM TO BE SOLVED: To provide a novel dosage form for improving the pharmacokinetics or bioavailability of a therapeutically active compound in the treatment of diseases such as pain and inflammation. A dosage form containing meloxicam, sulfobutyl ether β-cyclodextrin (SBEβCD), biscarbonate, and triptan, 1) containing the same amount of meloxicam, 2) not containing SBEβCD, and 3 ) Dosage form, which is an oral dosage form containing no biocarbonate and having a Tmax of meloxicam shorter than the reference dosage form. Solubility in water of less meloxicam and inclusion complex of sulfobutyl ether β- cyclodextrin, further K 2 CO 3 as a buffer, in tablets containing a combination of bicarbonate such as NaHCO 3, solubility and pharmacokinetic properties of meloxicam (organism Physiological availability, T max, etc.) improved. [Selection diagram] FIG. 11 |