| abstract |
PROBLEM TO BE SOLVED: To provide an antibody which specifically binds to CD38, which can kill CD38 + cells by inducing apoptosis, antibody-dependent cellular cytotoxicity (ADCC), and complement-dependent cellular cytotoxicity (ADCC). do. The antibody can be used as a preparation or in the production of a preparation, and the antibody is administered to a human subject at a safe therapeutic dose of about 20 mg / kg or less. In one embodiment, the formulation is for the treatment of CD38 + multiple myeloma in humans. [Selection diagram] None |