| abstract |
PROBLEM TO BE SOLVED: To increase the expression of major histocompatibility complex class I (MHC-I) antigen in cells, particularly on the surface of abnormal cells such as cancer cells, thereby enhancing the immunogenicity of the cells. To provide a method of using phenolic compounds. Also provided are pharmaceutical compositions containing curcphenol compounds and methods of their use, for example, for treating various cancers alone or in combination with other therapies. A method for increasing the surface expression of major histocompatibility complex class I (MHC-I) in a cell, comprising contacting the cell with a curcphenol compound. [Selection diagram] None |