| abstract |
PROBLEM TO BE SOLVED: To provide a pyrazolo and triazolobicyclic compound useful as a JAK3 inhibitor showing selectivity for JAK3. SOLUTION: The compound represented by the formula (I) or a pharmaceutically acceptable salt thereof is provided. Also provided are crystalline forms containing the compounds, pharmaceutical compositions, methods of using the compounds to treat gastrointestinal inflammatory diseases and other inflammatory diseases, as well as processes and intermediates useful in the preparation of the compounds. It also provides several crystalline forms of certain compounds (form 1, form 2, form 2b, form 3, and form 4). Also provided are pharmaceutical compositions comprising the compounds of the present disclosure or pharmaceutically acceptable salts thereof or the crystalline forms and pharmaceutically acceptable carriers of the present disclosure. [Selection diagram] None |