| abstract |
PROBLEM TO BE SOLVED: To provide an improved fibronectin domain scaffold protein that binds to PCSK9 for therapeutic treatment of atherosclerosis, hypercholesterolemia and other cholesterol-related diseases. A polypeptide comprising a fibronectin type III tenth domain ( 10 Fn3), wherein the 10 Fn3 has a modified amino acid sequence as compared to the corresponding loop sequence of the human 10 Fn3 domain. It has at least one loop selected from BC, DE and FG, and the polypeptide is a polypeptide that binds to PCSK9 (precursor protein convertase subtilisinkexin type 9). [Selection diagram] Fig. 6 |