abstract |
PROBLEM TO BE SOLVED: To provide a CD40 antibody and an antigen-binding portion thereof, and their use in the prevention and / or treatment of various diseases. An isolated antibody or antigen-binding portion thereof that binds to an epitope of human CD40 as defined by the topographical regions Cys62-Phe67, Grn79-Cys83, Arg90-Thr99 and Thr24-Cys37 of a particular sequence. An antagonist antibody, said isolated antibody or antigen-binding portion thereof. [Selection diagram] None |