| abstract |
PROBLEM TO BE SOLVED: To provide a growth hormone having an extended half-life. A growth hormone having a specific amino acid sequence in which one or more lysine residues at positions corresponding to 64, 141, and 194 from the N-terminus of the specific amino acid sequence are arginine. It is a replacement, extended half-life growth hormone. Also pharmaceutical compositions for the prevention and / or treatment of dwarfism, Kabuki syndrome, and / or Kearns-Sayer syndrome (KSS), comprising said growth hormone and pharmaceutically acceptable excipients. provide. [Selection diagram] Fig. 6 |