| abstract |
PROBLEM TO BE SOLVED: To provide an alternative composition and method for increasing red blood cells in a patient. The present invention is an activin-ActRII antagonist (eg, for increasing levels of red blood cells and hemoglobin in patients and for treating disorders associated with low levels of red blood cells or hemoglobin in patients in need of treatment, eg. , Activin-binding ActRIIa polypeptide, activin-binding ActRIIb polypeptide, anti-activin antibody, anti-ActRIIa antibody, anti-ActRIIb antibody, activin, ActR The use of small molecules and aptamers that target IIb or ActRIIa, as well as nucleic acids that reduce the expression of activin, ActRIIb or ActRIIa) is provided. [Selection diagram] None |