| abstract |
PROBLEM TO BE SOLVED: To provide a Bruton's tyrosine kinase (Btk) inhibitor. 1-((R) -3- (4-amino-3- (4-phenoxyphenyl) -1H-pyrazolo [3,4-d] pyrimidin-1-yl) piperidin-1-yl) prop -2-En-1-one and benzoic acid, succinic acid, 3-hydroxybenzoic acid, nicotine amide, 4-aminobenzoic acid, salicylic acid, sorbic acid, fumaric acid, salicylic acid, trans-katsura acid, 4-hydroxy It is co-crystallized with a co-crystal agent selected from benzoic acid, 1-hydroxy-2-naphthoic acid, sulfamic acid, 1,5-naphthalenedisulfonic acid, 2-ethoxybenzamide, 4-aminosalicylic acid, or stearic acid. [Selection diagram] Fig. 1 |