abstract |
PROBLEM TO BE SOLVED: To treat synthetic peptide compounds and complement-mediated diseases such as inflammatory diseases, autoimmune diseases, and microbial and bacterial infections; and non-complement-mediated diseases such as cystic fibrosis and various acute diseases. And its use for diagnosis. SOLUTION: The modification of a synthetic peptide of 15 amino acids from a Polar Assertant (PA) peptide, which is a scrambled peptide derived from a human astrovirus protein, is provided. For example, peptide mimetics of PA, peptide analogs and / or synthetic derivatives (eg, sarcosin derivatives) with modifications involving internal peptide substitutions and PEGylation at the N- and C-termini, as well as various. Provided is a method of selecting at least one synthetic peptide for treating a condition. [Selection diagram] FIG. 26C |