abstract |
PROBLEM TO BE SOLVED: To use in adoptive cell therapy, a molecule and cell having reduced immunogenicity, which specifically binds to the receptor tyrosine kinase-like orphan receptor 1 (ROR1), and a fully human antibody (antibody fragment). To provide a chimeric receptor that expresses human antibodies. An anti-ROR1 antibody containing an antibody fragment such as a ROR1 binding molecule, such as a variable heavy chain (VH) region, a single chain fragment, and a chimeric receptor containing the antibody, such as a chimeric antigen receptor (CAR), and the like. According to the genetically modified cells expressing the chimeric receptor, and the use of said binding molecules and cells in adoptive cell therapy. [Selection diagram] None |