| abstract |
PROBLEM TO BE SOLVED: To provide a chimeric antigen receptor that specifically binds to CCR4, and its use for treatment such as treating a malignant tumor in a subject. SOLUTION: (a) scFv containing a light chain variable domain ( VL ) and a heavy chain variable domain ( VH ), which specifically binds to CCR4; (b) a hinge and membrane derived from CD8. Penetration domains; (c) intracellular 4-1BB signaling domains; and (d) chimeric antigen receptors containing intracellular CD3 zeta signaling domains, wherein (a)-(d) are N-terminal to C-terminal. The chimeric antigen receptor is disclosed in the order of. The use of chimeric antigen receptors, such as for treating malignant tumors, is also disclosed. [Selection diagram] None |