| abstract |
PROBLEM TO BE SOLVED: To administer a composition containing an anti-estrogen agent, preferably a selective estrogen receptor regulator (SERM) such as trans-clomiphene, for the treatment of cancer and related diseases. An object of the present invention is a method for lowering the IGF-1 level of a subject in need thereof by administering a composition containing a SERM such as an anti-estrogen drug, preferably trans-clomiphene. To do. Subjects are human males with higher serum IGF-1 levels than normal, including, but not limited to, 300 ng / ml or higher, 350 ng / ml or higher, 400 ng / ml or higher, or 500 ng / ml or higher IGF-1 levels. Or it may be a woman. [Selection diagram] Fig. 1 |