| abstract |
PROBLEM TO BE SOLVED: To provide a cell preparation containing a pool and a concentrated mononuclear apoptotic cell population, and a method for preparing the cell preparation. A therapeutically irradiated mononuclear early apoptotic cell population comprising irradiated mononuclear cells in an early apoptotic state after induction of apoptosis, the analysis of said apoptotic cell population is at least 40%. The mononuclear cell anexin V-positive and at least 15% of the mononuclear cells propidium iodide (PI) positive, and the irradiated, mononuclear-enriched population of the early apoptotic cells were unirradiated cells. A reduced proportion of non-stationary non-apoptotic cells, suppressed cell activation of any living non-apoptotic cells, or reduced proliferation of any living non-apoptotic cells, or reduced proliferation compared to the population, including the population. An early apoptotic cell population, including any combination thereof. [Selection diagram] Fig. 1 |