| abstract |
PROBLEM TO BE SOLVED: To provide an antibody cytokine graft protein which binds to an interleukin 10 receptor and stimulates intracellular signal transduction through the receptor. (A) Complementarity determining regions (CDRs) with heavy chain variable regions (VH) containing HCDR1, HCDR2, HCDR3; (b) light chain variable regions (VL) containing LCDR1, LCDR2, LCDR3; c) An antibody cytokine graft protein comprising interleukin 10 (IL10) monomer molecules grafted onto the CDRs of the VH or VL. [Selection diagram] None |