abstract |
PROBLEM TO BE SOLVED: To provide a stable preparation of MYC-containing nanoparticles retaining biological activity. A composition comprising a population of bioactive nanoparticles comprising one or more MYC-containing polypeptides a. The average diameter of the bioactive nanoparticles is from about 80 nm to about 150 nm; b. A MYC-containing polypeptide nanoparticle composition containing anti-CD3 activated or anti-CD28 activated T cells under conditions suitable for cT cell proliferation, where the pH of the formulation is at least about pH 6.0 and about pH 8 or less. By contact with, one or more of the activation, survival, or proliferation of the T cells is with anti-CD3 activated or anti-CD28 activated T cells that are not in contact with the MYC polypeptide-containing composition. The composition, which increases in comparison. [Selection diagram] None |