abstract |
PROBLEM TO BE SOLVED: To increase exposure of a subject to administered cells by improving proliferation and / or persistence of administered cells to reduce the risk of toxicity and enhance efficacy, improved chimeric antigen receptor. Provision of adoptive cell therapy using body (CAR) -expressing cells. (A) A step of administering a first dose of chimeric antigen receptor (CAR) -expressing cells to a subject having a disease or condition, wherein the first dose is about 1 kilogram of subject body weight. The steps comprising 1x106 or less of the cells, about 1x108 or less of the cells, and / or about 1x108 or less of the cells per 1 m2 of subject and at least about 14 days or about 14 days or about after the start of administration of (b) (a). A method of treatment comprising administering to a subject a continuous dose of CAR-expressing cells longer than 14 days and less than about 28 days after the start of administration of (a). [Selection diagram] FIG. 1A |