| abstract |
PROBLEM TO BE SOLVED: To provide a polysubstituted aromatic compound useful for inhibiting thrombin and / or kallikrein. A formula-substituted pyrazole compound represented by (IV) (wherein, X is a bond, a substituted or unsubstituted alkylene, -O-, or -NR 8 - and is, Y is a bond, substituted or unsubstituted If it is alkylene, -O-, or -N-, but Y is -O-, then Z is bound, -C (O)-, substituted or unsubstituted, provided that W is absent. alkylene, -O-, or -NR 9 - (R 8 and R 9 are independently hydrogen, halogen, substituted or unsubstituted alkyl)).. [Selection diagram] None |