| abstract |
PROBLEM TO BE SOLVED: To provide a binding-induced transcription switch polypeptide, a nucleic acid containing a nucleotide sequence encoding the binding-induced transcription switch polypeptide, and a host cell genetically modified with the nucleic acid. SOLUTION: A chimeric Notch receptor polypeptide, a nucleic acid containing a nucleotide sequence encoding the chimeric Notch receptor polypeptide, and a host cell transduced and / or genetically modified with the nucleic acid are provided. Provided are transgenic organisms comprising a nucleic acid encoding a binding-induced transcriptional switch polypeptide and / or a chimeric Notch receptor polypeptide. Binding-induced transcriptional switch polypeptides and chimeric Notch receptor polypeptides are also useful in the various applications provided. [Selection diagram] None |