| abstract |
PROBLEM TO BE SOLVED: To improve the pharmacokinetics of an antigen-binding molecule, to increase the number of times an antigen-binding molecule binds to an antigen, an antigen-binding molecule having improved pharmacokinetics, and an antigen-binding to which the number of times an antigen-binding molecule binds to an antigen is improved. Provision of molecules and methods for producing them. An antigen-binding molecule having a KD (pH 5.8) / KD (pH 7.4) value of 2 or more, which is the ratio of KD at pH 5.8 to KD at pH 7.4 with respect to an antigen. A method for improving the pharmacokinetics of an antigen-binding molecule by making the antigen-binding activity of the antigen-binding molecule weaker than the antigen-binding activity at pH 7.4. [Selection diagram] None |