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filingDate 2020-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b428ba24a1fd49ceefae6959f24763ef
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d1daa2735c0307640c7b5d95e176db9
publicationDate 2021-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2021008488-A
titleOfInvention Methods and Compositions for Increasing Iduronate-2-sulfatase Activity in CNS
abstract PROBLEM TO BE SOLVED: To provide a method and a composition for treating a subject suffering from iduronate-2-sulfatase deficiency in CNS. SOLUTION: The method comprises systemically administering a therapeutically effective amount of a fusion antibody having isulonic acid-2-sulfatase activity to a subject, wherein the fusion antibody is (a) immunoglobulin heavy chain and isulonic acid-2. -Fusion protein containing the amino acid sequence of sulfatase, in which the amino acid sequence of isulonate-2-sulfatase is covalently linked to the carboxy terminal of the amino acid sequence of the immunoglobulin heavy chain; and (b) immunoglobulin light chain. A method in which a fusion antibody crosses the blood-brain barrier (BBB) and catalyzes the hydrolysis of the 2-sulfate group of L-iduronate-2-sulfate units of dermatane sulfate, heparan sulfate or heparin. [Selection diagram] None
priorityDate 2009-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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