| abstract |
【Task】 Provided is a drug / cancer therapeutic method in which a compound having MDM2 inhibitory activity and a DNA methyltransferase inhibitor are combined. SOLUTION: (3'R, 4'S, 5'R) -N-[(3R, 6S) -6-carbamoyltetrahydro-2H-pyran-3-yl] -6 "-chloro-4'-(2-chloro- 3-Fluoropyridine-4-yl) -4,4-dimethyl-2 "-oxo-1", 2 "-dihydrodispyro [cyclohexane-1,2'-pyrrolidine-3', 3" -indole] -5 '-Providing a pharmaceutical or combination therapy in combination with carboxamide or a pharmaceutically acceptable salt thereof and a DNA methyltransferase inhibitor. [Selection diagram] None |