http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2020536948-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B57-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-45 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-76 |
| filingDate | 2018-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2020536948-A |
| titleOfInvention | Manufacturing methods and intermediates for synthesizing intermediates for the antitumor drug Nilaparib |
| abstract | The present invention has disclosed a production method and an intermediate for synthesizing an intermediate for the antitumor drug niraparib. The present invention discloses a method for producing compound f, which comprises a step of subjecting compound e to a cyclization reaction shown below under the action of a base in a solvent to obtain compound f. The production method of the present invention does not require a step of reducing with a noble metal catalyst or using coupling and chiral division with a noble metal, has low requirements for equipment, is easy to operate, is advantageous for industrial production, and is a waste liquid containing heavy metals and phosphorus. Occurrence is avoided, the cost is low, and the ee value of the product is high. |
| priorityDate | 2017-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 128.