| abstract |
The present invention discloses a vitamin D analog preparation and a method for preparing the same. In order to solve the defect that it is difficult to satisfy the requirement of content uniformity in the conventional method for preparing a vitamin D analog drug and the drug is easily decomposed and converted in the granulation process, the present invention uses a twin-screw extrusion technique for the first time. To prepare a vitamin D analog preparation. In addition to seriously studying the preparation process of its solid preparations, with the widespread use of various vitamin D analogs as model medicines, alphacalcidol, eldecalcitol or calcitriol are preferably used. By preparing a solid formulation via a twin-screw extruder, its content uniformity meets the Pharmacopoeia regulations, the stability of the drug is significantly improved, and the quality of the drug is significantly improved. [Selection diagram] None |