| abstract |
Aspects of the present disclosure relate to filtration systems and methods for producing biologically produced products, which may include pharmaceutical and / or protein products. A particular biomanufacturing system described herein is a filter comprising a bioreactor (eg, a perfusion bioreactor, a chemostat) and multiple hollow fibers (eg, longitudinally aligned hollow fibers). Includes a filter probe containing a bundle. According to some embodiments, the center-to-center distance between any two hollow fibers in the fiber bundle at one or more points along the length of the fiber bundle is relatively large (eg, fiber). Greater than or equal to the average outer diameter of the bundle hollow fibers, greater than or equal to 1.1 times the minimum diameter of the two hollow fibers). In some embodiments, the hollow fibers in the fiber bundle are arranged in a single row (eg, a hexagonal, straight, annular, or rectangular row). |