| abstract |
New small molecules with a substituted pyrimidine or substituted condensed pyrimidine core structure, and their use for regulating glucocerebrosidase activity are disclosed. Gaucher's disease, as well as neurological disorders and disorders such as Parkinson's disease associated with abnormal glucocerebrosidase activity, dementia with Lewy bodies, and hereditary and sporadic synucleinopathy including multiple system atrophy, gluco Also disclosed are pharmaceutical compositions containing small molecules that may be administered in a manner that treats a disease or disorder associated with celebrosidase activity. Small molecules may contain fluorophores or fluorophores for the purpose of preparing fluorescent probes for use in high-throughput screening methods to identify novel modulators of glucocerebrosidase activity via fluorescent polarization. May be conjugated to. [Selection diagram] None |