abstract |
The present invention provides anti-Her2 Nanobodies and their coding sequences and uses. Specifically, the present invention provides Nanobodies to human epidermal growth factor receptor-2 (Her2/ERBB2). The present invention discloses such Nanobodies and gene sequences encoding the Nanobodies, corresponding expression carriers and host cells capable of expressing the Nanobodies, as well as methods of producing the Nanobodies of the present invention and their related uses. The present invention may also provide the immunoconjugate of the Nanobody and its application, especially in the diagnosis and treatment of Her2-positive tumors. |