| abstract |
The present invention relates to an azaaryl derivative having CSF-1R inhibitory activity, a method for producing the same, and an application thereof. The series of compounds according to the invention have the structure of formula (I) below, the definition of each substituent being as described in the description and the claims. A series of compounds according to the invention are useful for treating cancer, tumors, autoimmune diseases, metabolic or metastatic diseases, especially ovarian cancer, pancreatic cancer, prostate cancer, breast cancer, cervical cancer, glioblastoma, multiple bone marrow. It is widely applicable to the manufacture of drugs for treating tumors, metabolic diseases, neurodegenerative diseases, metastases of primary tumor sites or bone metastatic cancer, and is expected to be developed as a new-generation CSF-1R inhibitor drug. There is. [Chemical 1] |