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filingDate 2018-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2020-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2020522996-A
titleOfInvention Method for preparing mesenchymal stem cell-derived exosomes by drug pretreatment
abstract The present invention provides a method for preparing mesenchymal stem cell-derived exosomes by drug pretreatment. The method for preparing mesenchymal stem cell-derived exosomes of the present invention comprises pretreating mesenchymal stem cells with a statin drug and culturing the mesenchymal stem cells treated so as to collect secreted exosomes. Further, the present invention provides the use of a statin drug for the preparation of a preparation for improving the anti-apoptotic ability and/or homing promoting ability of mesenchymal stem cells, and the myocardial infarction microenvironment improving effect and/or the effect of mesenchymal stem cells on myocardial infarction and/or Provided is the use of statins for the preparation of a formulation that promotes the secretion of exosomes with myocardial repair capacity. [Selection diagram] None
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