| abstract |
The present invention provides benzofuran and benzothiophene derivatives of formula (I), wherein (R 1 ) n , R 2 , R 3 , R 4a , R 4b , R 5a , R 5b and Ar 1 are described in the specification. And their use in the treatment of cancer by modulating the immune response, including reactivation of the immune system in tumors. The present invention further provides novel benzofuran and benzothiophene derivatives of formula (II) and their use as pharmaceuticals, their preparation, their pharmaceutically acceptable salts and their use as pharmaceuticals, 1 or 2 It relates to pharmaceutical compositions comprising the compounds of formula (I) above and their use, in particular as modulators of the prostaglandin 2 receptors EP2 and/or EP4. [Chemical 1] [Selection diagram] None |