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filingDate 2018-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2020-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2020519296-A
titleOfInvention DNA methylation and mutation analysis method for bladder cancer monitoring
abstract The present disclosure relates to methods of monitoring bladder cancer patients and analyzing patient samples for the presence of methylated DNA and optionally specific gene mutations. In some embodiments, the analysis result correlates with a clinical endpoint such as bladder cancer recurrence risk. The above-described method includes, for example, obtaining a urine sediment sample from a patient; converting DNA derived from the sample into bisulfite; , ONECUT2, KLF2, OSR1, SOX1, EOMES, DDX25, and TMEM106A, and determining the amount and/or concentration of methylated DNA in the sample from a set of genes comprising at least four genes. ..
priorityDate 2017-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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