| abstract |
The present invention provides a method for determining the selective binding ability of a peptidic epitope to proteins CD1a, CD1b and/or CD1c based on the activation level of NKT cells, and modifying the corresponding epitope or its adjacent region. Thus, it relates to a method of increasing or decreasing the selective binding of a peptidic epitope to the proteins CD1a, CD1b and/or CD1c, the corresponding modified epitope and activated NKT cells or parts thereof obtained by said method. |