| abstract |
The present disclosure features novel lipids and compositions containing the same. The nanoparticle composition comprises the novel lipid as well as additional lipids such as phospholipids, structured lipids, and PEG lipids. A nanoparticle composition further comprising a therapeutic and / or prophylactic agent, such as RNA, is provided for treating and / or preventing a mammalian cell or organ, eg, for modulating polypeptide, protein or gene expression. Useful for delivery. |