abstract |
Disclosed are methods and compositions related to immunoconjugates. Specifically disclosed are immune complexes that include the Fc portion of IgG3, as well as the light chain of Factor VII or Factor VII. Also disclosed is an immune complex protein, which comprises an IgG1 and IgG3 immunoglobulin hybrid Fc region complexed with Factor VII. These immune complexes can target tissue factor (TF) expressing cells. |