http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2020510682-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-16122 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-11 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6893 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-569 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-574 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-56983 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-569 |
| filingDate | 2017-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2020510682-A |
| titleOfInvention | Markers for detecting highly pathogenic influenza virus and uses thereof |
| abstract | The present invention relates to a marker for detecting a highly pathogenic virus and a use thereof, and more specifically, a marker for detecting a highly pathogenic virus comprising a protein mutant in which the amino acids at positions 68 and 69 of the PB1-F2 protein have been substituted. A composition for detecting a highly pathogenic virus comprising a preparation for measuring the protein variant, a detection kit containing the same, a method for detecting a highly pathogenic virus comprising a step of measuring the protein variant, The present invention relates to an antiviral composition for an influenza A virus, which comprises, as an active ingredient, a binding inhibitor of a PB1-F2 protein and a DDX3 in which amino acids have been substituted, and a method for screening an antiviral substance against an influenza A virus. In the present invention, the correlation between the 1918 PB1-F2 protein and the high pathogenicity of the virus and the molecular mechanism thereof were first elucidated, and as a result, the amino acids 68 and 69 were substituted in the PB1-F2 protein sequence of the influenza virus. The resulting protein mutant can be used as a marker for detecting a highly pathogenic virus, and by measuring the mutant, a highly pathogenic virus can be usefully detected. In addition, the mechanism of avoiding the innate immune response of a virus by the PB1-F2 protein mutant newly elucidated in the present invention provides a new understanding for the development of an antiviral formulation, and the composition for an antiviral according to the present invention. Can be usefully used in the development of antiviral therapeutic formulations. [Selection diagram] FIG. |
| priorityDate | 2016-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 377.