Predicate |
Object |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2878 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6831 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6867 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6889 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-68 |
filingDate |
2017-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate |
2020-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
JP-2020504736-A |
titleOfInvention |
Amanitin antibody conjugate |
abstract |
The present invention relates to (a) an amatoxin comprising (a) amino acid 4 having a 6'-deoxy position; and (ii) an amatoxin containing amino acid 8 having an S-deoxy position; And a conjugate comprising: (ii) a BCMA binding moiety comprising a heavy chain constant region comprising a D265C mutation; and (c) a protease cleavable linker that binds said amatoxin and said target binding moiety. The invention further relates to a pharmaceutical composition comprising such a conjugate, especially for use in the treatment of multiple myeloma. |
priorityDate |
2016-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |