| abstract |
The invention relates to the field of therapy, in particular dermatology. We herein disclose an inhibitor of matrix metalloproteinase-9 (MMP9) as an active molecule for use in preventing, treating, or alleviating skin depigmentation disorders in a subject in need thereof. Are described for the first time, and compositions and kits containing such inhibitors and their use are described. We further evaluate methods for screening for appropriate pharmaceutically active molecules to prevent, treat, or alleviate depigmentation disorders, and to evaluate the efficacy of treatments for depigmentation disorders, including inhibitors of MMP9. A method for monitoring the course of a depigmentation disorder for or for a subject exposed to such treatment is described. |