| abstract |
Provided herein is a novel method for producing a fixed, non-antagonistic molar ratio of a drug in and around a bone environment over a desired period of time. The method comprises administering a pharmaceutical composition comprising, in addition to a second therapeutic agent, a bone-targeted therapeutic agent capable of releasing a drug payload from the bone surface, thereby reducing bone disease and bone-related diseases. To be treated. Such methods are useful for treating bone disorders and bone-related disorders, such as cancer-induced bone disorders, osteomyelitis and bone infections, bone pain and inflammatory bone disorders, metabolic disorders, and others. It is useful in. |